| First Author | Pelkonen A | Year | 2011 |
| Journal | Neurosci Lett | Volume | 487 |
| Issue | 3 | Pages | 350-3 |
| PubMed ID | 21029764 | Mgi Jnum | J:168149 |
| Mgi Id | MGI:4887282 | Doi | 10.1016/j.neulet.2010.10.054 |
| Citation | Pelkonen A, et al. (2011) Neuromuscular pathology in mice lacking alpha-synuclein. Neurosci Lett 487(3):350-3 |
| abstractText | This work was undertaken in order to study the possible role of alpha-synuclein in the function of the neuro-muscular junction in skeletal muscles. Repeated stimulation of skeletal muscle motor neurons revealed signs of neuromuscular pathology in alpha-synuclein null mutated (C57Bl/6JOlaHsd) and knockout (B6;129X1-Snca(tm1Rosl)/J) mice. This stimulation produced repetitive compound muscle action potentials in both lines of alpha-synuclein deficient mice. Muscle strength and muscle coordination during ambulation were unaffected, though motor learning was slower in alpha-synuclein deficient mice in the Rotarod test. We conclude that alpha-synuclein may play a role in acetylcholine compartmentalization at the neuromuscular junction, and in the fine control of activity of skeletal muscles. |
