| First Author | Shahneh F | Year | 2021 |
| Journal | Blood | Volume | 137 |
| Issue | 11 | Pages | 1517-1526 |
| PubMed ID | 32932520 | Mgi Jnum | J:336892 |
| Mgi Id | MGI:6724668 | Doi | 10.1182/blood.2020005407 |
| Citation | Shahneh F, et al. (2021) Specialized regulatory T cells control venous blood clot resolution through SPARC. Blood 137(11):1517-1526 |
| abstractText | The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg population that forms the matricellular acid- and cysteine-rich protein SPARC (secreted protein acidic and rich in cysteine) and show that SPARC enhances monocyte MMP activity and that SPARC+ Tregs are crucial for blood clot resorption. By comparing different treatment times, we define a therapeutic window of Treg expansion that accelerates clot resorption. |
