| First Author | Miettinen HE | Year | 2001 |
| Journal | J Clin Invest | Volume | 108 |
| Issue | 11 | Pages | 1717-22 |
| PubMed ID | 11733567 | Mgi Jnum | J:73138 |
| Mgi Id | MGI:2154615 | Doi | 10.1172/JCI13288 |
| Citation | Miettinen HE, et al. (2001) Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice. J Clin Invest 108(11):1717-22 |
| abstractText | Mammalian female fertility depends on complex interactions between the ovary and the extraovarian environment (e.g., the hypothalamic-hypophyseal ovarian axis). The role of plasma lipoproteins in fertility was examined using HDL-receptor SR-BI knockout (KO) mice. SR-BI KO females have abnormal HDLs, ovulate dysfunctional oocytes, and are infertile. Fertility was restored when the structure and/or quantity of abnormal HDL was altered by inactivating the apoAI gene or administering the cholesterol-lowering drug probucol. This suggests that abnormal lipoprotein metabolism can cause murine infertility - implying a functional hepatic-ovarian axis - and may contribute to some forms of human female infertility. |
