| First Author | Szanto A | Year | 2010 |
| Journal | Immunity | Volume | 33 |
| Issue | 5 | Pages | 699-712 |
| PubMed ID | 21093321 | Mgi Jnum | J:167002 |
| Mgi Id | MGI:4866967 | Doi | 10.1016/j.immuni.2010.11.009 |
| Citation | Szanto A, et al. (2010) STAT6 transcription factor is a facilitator of the nuclear receptor PPARgamma-regulated gene expression in macrophages and dendritic cells. Immunity 33(5):699-712 |
| abstractText | Peroxisome proliferator-activated receptor gamma (PPARgamma) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammatory milieu show cell type specification as a result of altered gene expression. We demonstrate here a mechanism how inflammatory molecules modulate PPARgamma signaling in distinct subsets of cells. Proinflammatory molecules inhibited whereas interleukin-4 (IL-4) stimulated PPARgamma activity in macrophages and DCs. Furthermore, IL-4 signaling augmented PPARgamma activity through an interaction between PPARgamma and signal transducer and activators of transcription 6 (STAT6) on promoters of PPARgamma target genes, including FABP4. Thus, STAT6 acts as a facilitating factor for PPARgamma by promoting DNA binding and consequently increasing the number of regulated genes and the magnitude of responses. This interaction, underpinning cell type-specific responses, represents a unique way of controlling nuclear receptor signaling by inflammatory molecules in immune cells. |
