| First Author | Rodriguez-Sosa M | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 7 | Pages | 3135-9 |
| PubMed ID | 11907063 | Mgi Jnum | J:75481 |
| Mgi Id | MGI:2176674 | Doi | 10.4049/jimmunol.168.7.3135 |
| Citation | Rodriguez-Sosa M, et al. (2002) Cutting edge: susceptibility to the larval stage of the Helminth parasite Taenia crassiceps is mediated by Th2 response induced via STAT6 signaling. J Immunol 168(7):3135-9 |
| abstractText | Using STAT6(-/-) BALB/c mice, we analyzed the role of STAT6-induced Th2 response in determining the outcome of murine cysticercosis caused by the helminth parasite Taenia crassiceps. After T. crassiceps infection, wild-type BALB/c mice developed a strong Th2-like response; produced high levels of IgG1, IgE, IL-4, as well as IL-13; and remained susceptible to T. crassiceps. In contrast, similarly infected STAT6(-/-) mice mounted a strong Th1-like response; produced high levels of IgG2a, IL-12, IFN-gamma, as well as nitric oxide; and efficiently controlled T. crassiceps infection. These findings demonstrate that Th2-like response induced via STAT6-mediated signaling pathway mediates susceptibility to T. crassiceps and, furthermore, that unlike the case in most helminths, immunity against T. crassiceps is mediated by a Th1-like rather than Th2-like response. |
