| First Author | Li Z | Year | 2011 |
| Journal | Nat Immunol | Volume | 12 |
| Issue | 2 | Pages | 178-85 |
| PubMed ID | 21217760 | Mgi Jnum | J:168252 |
| Mgi Id | MGI:4887510 | Doi | 10.1038/ni.1983 |
| Citation | Li Z, et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol 12(2):178-85 |
| abstractText | Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was associated with reduced expression of KLF2 and S1P(1). We also found that ECM1 could directly bind the interleukin-2 (IL-2) receptor to inhibit IL-2 signaling and activate S1P(1) expression. Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression. |
