| First Author | Fang TC | Year | 2007 |
| Journal | Immunity | Volume | 27 |
| Issue | 1 | Pages | 100-10 |
| PubMed ID | 17658278 | Mgi Jnum | J:123632 |
| Mgi Id | MGI:3718933 | Doi | 10.1016/j.immuni.2007.04.018 |
| Citation | Fang TC, et al. (2007) Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27(1):100-10 |
| abstractText | Notch signaling plays multiple roles to direct diverse decisions regarding cell fate during T cell development. During helper T (Th) cell differentiation, Notch is involved in generating optimal Th2 cell responses. Here, we present data investigating how Notch mediates Th2 cell differentiation. Notch showed a CD4(+) T cell intrinsic role in promoting IL-4 expression that required GATA-3. In the absence of Notch signals, Gata3 expression was markedly diminished. Introduction of an activated allele of Notch1 into CD4(+) T cells led to the specific and direct upregulation of a developmentally regulated Gata3 transcript that included the exon 1a sequences. Furthermore, Notch acted in parallel with GATA-3 to synergistically activate IL-4 expression. Together, these data implicate Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses. |
