| First Author | Zhu J | Year | 2002 |
| Journal | Immunity | Volume | 16 |
| Issue | 5 | Pages | 733-44 |
| PubMed ID | 12049724 | Mgi Jnum | J:113530 |
| Mgi Id | MGI:3686926 | Doi | 10.1016/s1074-7613(02)00317-5 |
| Citation | Zhu J, et al. (2002) Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 16(5):733-44 |
| abstractText | IL-4 is important in Th2 differentiation and in cell expansion. Stat6 is necessary and sufficient for both functions. Although Gata3 is critical for Th2 polarization, it is not sufficient to mediate IL-4-driven cell expansion. We report that growth factor independent-1 (Gfi-1), a Stat6-dependent transcriptional repressor, strikingly increases Th2 cell expansion by promoting proliferation and preventing apoptosis. Cells infected with a Gfi-1 retrovirus show striking enhancement of IL-2-induced Stat5 phosphorylation and repression of p27(Kip-1) expression, suggesting a potential mechanism for the Gfi-1 growth effect. The synergy of Gfi-1 and Gata3 provides a mechanism through which IL-4 could selectively promote Th2 cell expansion. |
