| First Author | Carty SA | Year | 2014 |
| Journal | PLoS One | Volume | 9 |
| Issue | 9 | Pages | e106659 |
| PubMed ID | 25207963 | Mgi Jnum | J:221518 |
| Mgi Id | MGI:5640909 | Doi | 10.1371/journal.pone.0106659 |
| Citation | Carty SA, et al. (2014) Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. PLoS One 9(9):e106659 |
| abstractText | Interleukin (IL)-4 is a cytokine classically associated with CD4(+) T helper type 2 differentiation, but has been recently shown to also be required for the development of CD8(+) innate-like lymphocytes. CD8(+) innate-like lymphocytes are non-conventional lymphocytes that exhibit characteristics typically associated with memory CD8(+) T cells, including expression of the T-box transcription factor Eomesodermin (Eomes). Here we investigate the signaling pathways required for IL-4 induction of Eomes and CD8(+) innate-like lymphocyte markers in murine CD8SP thymocytes and peripheral CD8(+) T cells. We demonstrate that IL-4 is sufficient to drive Eomes expression and the CD8(+) innate-like lymphocyte phenotype through cooperation between STAT6- and Akt-dependent pathways. Furthermore, we show that while IL-4 has little effect on the induction of Eomes in the setting of robust T cell receptor (TCR) activation, this cytokine promotes Eomes in the setting of attenuated TCR stimulation in mature CD8(+) T cells suggesting that cytokine signaling pathways may direct cell fate when TCR signals are limiting. |
