| First Author | Zaph C | Year | 2008 |
| Journal | J Exp Med | Volume | 205 |
| Issue | 10 | Pages | 2191-8 |
| PubMed ID | 18762568 | Mgi Jnum | J:141183 |
| Mgi Id | MGI:3817381 | Doi | 10.1084/jem.20080720 |
| Citation | Zaph C, et al. (2008) Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med 205(10):2191-8 |
| abstractText | Alterations in the composition of intestinal commensal bacteria are associated with enhanced susceptibility to multiple inflammatory diseases, including those conditions associated with interleukin (IL)-17-producing CD4(+) T helper (Th17) cells. However, the relationship between commensal bacteria and the expression of proinflammatory cytokines remains unclear. Using germ-free mice, we show that the frequency of Th17 cells in the large intestine is significantly elevated in the absence of commensal bacteria. Commensal-dependent expression of the IL-17 family member IL-25 (IL-17E) by intestinal epithelial cells limits the expansion of Th17 cells in the intestine by inhibiting expression of macrophage-derived IL-23. We propose that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis. |
