| First Author | Blaeser F | Year | 2001 |
| Journal | Am J Physiol Endocrinol Metab | Volume | 281 |
| Issue | 5 | Pages | E931-7 |
| PubMed ID | 11595648 | Mgi Jnum | J:72562 |
| Mgi Id | MGI:2153248 | Doi | 10.1152/ajpendo.2001.281.5.E931 |
| Citation | Blaeser F, et al. (2001) CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells. Am J Physiol Endocrinol Metab 281(5):E931-7 |
| abstractText | The calcium/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is expressed in male germ cells and spermatids and has been implicated in controlling the differentiation of germ cells into mature spermatozoa. The function of CaMKIV/Gr in spermatogenesis was investigated using CaMKIV/Gr-deficient mice generated by targeted gene disruption. CaMKIV/Gr-deficient males exhibited normal spermatogenesis, and their fertility was similar to that of wild-type littermates. Notwithstanding the function of CaMKIV/Gr as an activator of cAMP response element (CRE)-dependent transcription, mRNA levels of several testis-specific CRE modulator (CREM)-regulated genes were unaltered. These results indicate that CaMKIV/Gr is not essential for spermatogenesis or for CRE-regulated gene transcription in the testis. |
