| First Author | Fernández-Moreno C | Year | 2004 |
| Journal | FEBS Lett | Volume | 557 |
| Issue | 1-3 | Pages | 64-8 |
| PubMed ID | 14741342 | Mgi Jnum | J:87585 |
| Mgi Id | MGI:3027219 | Doi | 10.1016/s0014-5793(03)01445-5 |
| Citation | Fernandez-Moreno C, et al. (2004) Increased leptin and white adipose tissue hypoplasia are sexually dimorphic in Lif null/Igf-I haploinsufficient mice. FEBS Lett 557(1-3):64-8 |
| abstractText | We previously showed cooperation of leukemia inhibitory factor (LIF) and insulin-like growth factor I (IGF-I) during development. Mice doubly deficient in LIF and IGF-I died at birth. We now analyze the possible combined influence of both factors on postnatal growth. The haploinsufficiency of the Igf-I gene on a Lif null background caused a marked reduction in body mass index and white adipose tissue only in female mice. These animals had increased leptin, increased serum IGF-I and apparent substitution of white adipose tissue by brown adipose tissue. The complex interrelationships between LIF and IGF-I in regulating weight thus involve sexually dimorphic effects on adipose tissue differentiation and circulating leptin. |
