| First Author | Pedranzini L | Year | 2004 |
| Journal | J Clin Invest | Volume | 114 |
| Issue | 5 | Pages | 619-22 |
| PubMed ID | 15343379 | Mgi Jnum | J:92600 |
| Mgi Id | MGI:3054117 | Doi | 10.1172/JCI22800 |
| Citation | Pedranzini L, et al. (2004) Stat3 is required for the development of skin cancer. J Clin Invest 114(5):619-22 |
| abstractText | Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is constitutively activated in a variety of human malignancies, including prostate, lung, brain, breast, and squamous cell carcinomas. Inhibition of activated Stat3 leads to decreased proliferation and apoptosis of many cancer-derived cell lines, while the introduction of a constitutively activated form of Stat3 into immortalized human breast epithelial cells and rodent fibroblasts results in cellular transformation. Collectively, these data suggest a role for Stat3 in oncogenesis. A new study from Chan et al. is the first to demonstrate a requirement for Stat3 in de novo epithelial carcinogenesis in vivo. Using the two-step model of chemically induced skin carcinogenesis, the authors demonstrated that mice deficient in Stat3 were completely resistant to skin tumor development. |
