| First Author | Nunomura S | Year | 2021 |
| Journal | Biochem Biophys Res Commun | Volume | 549 |
| Pages | 27-33 | PubMed ID | 33662665 |
| Mgi Jnum | J:305939 | Mgi Id | MGI:6705952 |
| Doi | 10.1016/j.bbrc.2021.02.075 | Citation | Nunomura S, et al. (2021) Epithelial SOX11 regulates eyelid closure during embryonic eye development. Biochem Biophys Res Commun 549:27-33 |
| abstractText | Fibroblast growth factor (FGF10)-mediated signals are essential for embryonic eyelid closure in mammals. Systemic SOX11-deficient mice are born with unclosed eyelids, suggesting a possible role of SOX11 in eyelid closure. However, the underlying mechanisms of this process remain unclear. In this study, we show that epithelial deficiency of SOX11 causes a defect in the extension of the leading edge of the eyelid, leading to failure of embryonic eyelid closure. c-Jun in the eyelid is a transcription factor downstream of FGF10 required for the extension of the leading edge of the eyelid, and c-Jun level was decreased in epithelial SOX11-deficient embryos. These results suggest that epithelial SOX11 plays an important role in embryonic eyelid closure. |
