| First Author | Noguchi S | Year | 2019 |
| Journal | Commun Biol | Volume | 2 |
| Pages | 37 | PubMed ID | 30701202 |
| Mgi Jnum | J:272251 | Mgi Id | MGI:6283886 |
| Doi | 10.1038/s42003-018-0279-0 | Citation | Noguchi S, et al. (2019) Beclin 1 regulates recycling endosome and is required for skin development in mice. Commun Biol 2:37 |
| abstractText | Beclin 1 is a key regulator of autophagy and endocytosis. However, its autophagy-independent functions remain poorly understood. Here, we report that Beclin 1 regulates recycling endosome and is required for skin development in vivo. We first established keratinocyte-specific Beclin 1-knockout mice and found that these mutant mice died owing to severe impairment of epidermal barrier. Beclin 1 plays a role in autophagy and the endocytic pathway in cooperation with Atg14 and UVRAG, respectively, and keratinocyte-specific Atg14-knockout mice do not show any abnormal phenotypes, suggesting that Beclin 1 has a role in skin development via the endocytic pathway. Furthermore, we found that Beclin 1 deficiency causes mislocalization of integrins via a defect of recycling endosome, abnormal cell detachment of basal cells and their immature differentiation, and abnormal skin development. These results provide the first genetic evidence showing the roles of Beclin 1 in recycling endosome and skin development. |
