| First Author | Ito T | Year | 2017 |
| Journal | J Exp Med | Volume | 214 |
| Issue | 10 | Pages | 3037-3050 |
| PubMed ID | 28811323 | Mgi Jnum | J:249547 |
| Mgi Id | MGI:5923509 | Doi | 10.1084/jem.20162108 |
| Citation | Ito T, et al. (2017) IL-22 induces Reg3gamma and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med 214(10):3037-3050 |
| abstractText | Previous studies have shown that IL-22, one of the Th17 cell-related cytokines, plays multiple roles in regulating allergic airway inflammation caused by antigen-specific Th2 cells; however, the underlying mechanism remains unclear. Here, we show that allergic airway inflammation and Th2 and Th17 cytokine production upon intratracheal administration of house dust mite (HDM) extract, a representative allergen, were exacerbated in IL-22-deficient mice. We also found that IL-22 induces Reg3gamma production from lung epithelial cells through STAT3 activation and that neutralization of Reg3gamma significantly exacerbates HDM-induced eosinophilic airway inflammation and Th2 cytokine induction. Moreover, exostatin-like 3 (EXTL3), a functional Reg3gamma binding protein, is expressed in lung epithelial cells, and intratracheal administration of recombinant Reg3gamma suppresses HDM-induced thymic stromal lymphopoietin and IL-33 expression and accumulation of type 2 innate lymphoid cells in the lung. Collectively, these results suggest that IL-22 induces Reg3gamma production from lung epithelial cells and inhibits the development of HDM-induced allergic airway inflammation, possibly by inhibiting cytokine production from lung epithelial cells. |
