| First Author | Miwa K | Year | 1998 |
| Journal | Nat Med | Volume | 4 |
| Issue | 11 | Pages | 1287-92 |
| PubMed ID | 9809553 | Mgi Jnum | J:50775 |
| Mgi Id | MGI:1309713 | Doi | 10.1038/3276 |
| Citation | Miwa K, et al. (1998) Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Nat Med 4(11):1287-92 |
| abstractText | Fas ligand is a well-characterized apoptosis inducer. Here we demonstrate that Fas ligand induces the processing and secretion of interleukin-1beta (IL-1beta) in peritoneal exudate cells. This IL-1beta secretion is independent of IL-1beta converting enzyme (caspase 1), yet it is inhibited by caspase inhibitors, indicating that a caspase(s) in addition to IL-1beta converting enzyme can process IL-1beta. Inoculation of tumor cells expressing Fas ligand into wild-type mice induces a massive neutrophil infiltration that is, in contrast, suppressed in IL-1alpha/beta knockout mice. These results demonstrate a newly discovered role for Fas ligand in inflammation, and challenge the dogma that apoptosis does not induce inflammation. |
