| First Author | Scharschmidt TC | Year | 2008 |
| Journal | J Invest Dermatol | Volume | 128 |
| Issue | 5 | Pages | 1061-4 |
| PubMed ID | 18408744 | Mgi Jnum | J:136282 |
| Mgi Id | MGI:3795825 | Doi | 10.1038/sj.jid.5701201 |
| Citation | Scharschmidt TC, et al. (2008) Modeling atopic dermatitis with increasingly complex mouse models. J Invest Dermatol 128(5):1061-4 |
| abstractText | Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder that affects approximately 15% of children in the United States. A complex disorder, AD is characterized by both skin barrier impairment and immunologic abnormalities, including decreased innate immune function and a polarized adaptive immune response. Mouse models have demonstrated the complex interdependence of immune cell-keratinocyte interactions and teased apart gene-environment relationships in a controlled setting. In this issue, Nagelkerken et al. present a mouse model with transgenic expression of apolipoprotein C1 that disrupts the skin lipid barrier and manifests many hallmark features of AD. |
