| First Author | Molè MA | Year | 2021 |
| Journal | Cell Rep | Volume | 34 |
| Issue | 10 | Pages | 108834 |
| PubMed ID | 33691117 | Mgi Jnum | J:306167 |
| Mgi Id | MGI:6714781 | Doi | 10.1016/j.celrep.2021.108834 |
| Citation | Mole MA, et al. (2021) Integrin beta1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition. Cell Rep 34(10):108834 |
| abstractText | At implantation, the embryo establishes contacts with the maternal endometrium. This stage is associated with a high incidence of preclinical pregnancy losses. While the maternal factors underlying uterine receptivity have been investigated, the signals required by the embryo for successful peri-implantation development remain elusive. To explore these, we studied integrin beta1 signaling, as embryos deficient for this receptor degenerate at implantation. We demonstrate that the coordinated action of pro-survival signals and localized actomyosin suppression via integrin beta1 permits the development of the embryo beyond implantation. Failure of either process leads to developmental arrest and apoptosis. Pharmacological stimulation through fibroblast growth factor 2 (FGF2) and insulin-like growth factor 1 (IGF1), coupled with ROCK-mediated actomyosin inhibition, rescues the deficiency of integrin beta1, promoting progression to post-implantation stages. Mutual exclusion between integrin beta1 and actomyosin seems to be conserved in the human embryo, suggesting the possibility that these mechanisms could also underlie the transition of the human epiblast from pre- to post-implantation. |
