| First Author | Nguyen H | Year | 2009 |
| Journal | Nat Genet | Volume | 41 |
| Issue | 10 | Pages | 1068-75 |
| PubMed ID | 19718027 | Mgi Jnum | J:155012 |
| Mgi Id | MGI:4412144 | Doi | 10.1038/ng.431 |
| Citation | Nguyen H, et al. (2009) Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet 41(10):1068-75 |
| abstractText | Single-layered embryonic skin either stratifies to form epidermis or responds to Wnt signaling (stabilized beta-catenin) to form hair follicles. Postnatally, stem cells continue to differentially use Wnt signaling in long-term tissue homeostasis. We have discovered that embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors. Using loss-of-function studies and transcriptional analyses, we uncovered consequences to the absence of Tcf3 and Tcf4 in skin that only partially overlap with those caused by beta-catenin deficiency. We established roles for Tcf3 and Tcf4 in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that Tcf proteins have both Wnt-dependent and Wnt-independent roles in lineage determination. |
