| First Author | Leybova L | Year | 2024 |
| Journal | Dev Cell | PubMed ID | 39413781 |
| Mgi Jnum | J:358270 | Mgi Id | MGI:7779460 |
| Doi | 10.1016/j.devcel.2024.09.022 | Citation | Leybova L, et al. (2024) Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding. Dev Cell |
| abstractText | The bending of simple cellular sheets into complex three-dimensional (3D) forms requires developmental patterning cues to specify where deformations occur, but how positional information directs morphological change is poorly understood. Here, we investigate how morphogen signaling and cell fate diversification contribute to the morphogenesis of murine hair placodes, in which collective cell movements transform radially symmetric primordia into bilaterally symmetric tubes. Through live imaging and 3D volumetric reconstructions, we demonstrate that Wnt and Shh establish radial patterns of cell fate, cell morphology, and movement within developing placodes. Cell fate diversity at different radial positions provides unique and essential contributions to placode morphogenesis. Further, we show that downstream of radial patterning, gradients of classical cadherin expression are required for efficient epithelial rearrangements. Given that the transformation of epithelial discs into 3D tubes is a common morphological motif used to shape diverse organ primordia, mechanisms of radially patterned morphogenesis are likely highly conserved across evolution. |
