| First Author | Jhaveri S | Year | 1996 |
| Journal | J Comp Neurol | Volume | 374 |
| Issue | 1 | Pages | 41-51 |
| PubMed ID | 8891945 | Mgi Jnum | J:35624 |
| Mgi Id | MGI:83071 | Doi | 10.1002/(SICI)1096-9861(19961007)374:1<41::AID-CNE3>3.0.CO;2-N |
| Citation | Jhaveri S, et al. (1996) Excess nerve growth factor in the periphery does not obscure development of whisker-related patterns in the rodent brain. J Comp Neurol 374(1):41-51 |
| abstractText | We have addressed the issue of whether or not peripherally expressed nerve growth factor (NGF) influences the formation of whisker-specific patterns in the brain by regulating the survival of sensory neurons. Transgenic mice that overexpress an NGF cDNA in the skin were examined. In these animals, excess NGF expression is controlled by promoter and enhancer sequences of a keratin gene, thus restricting the higher levels of NGF expression to basal keratinocytes of the epidermis. Twice the number of trigeminal sensory neurons survive in transgenic mice as in normal animals, and a corresponding hyperinnervation of the whisker pad is noted, both around the vibrissa follicles and along the intervibrissal epidermis. However, the increased survival of sensory neurons and the enhanced peripheral projections do not interfere with the development of whisker-specific patterns in the trigeminal brainstem, in the ventrobasal thalamic complex or in the face-representation region of the primary somatosensory (SI) cortex. These results demonstrate that vibrissa-related central patterns are able to form in the virtual absence of trigeminal ganglion cell death and suggest that mechanisms other than a selective elimination of sensory neurons control the development of whisker-specific neural patterns in the brain. |
