| First Author | Jansz N | Year | 2018 |
| Journal | Cell Rep | Volume | 25 |
| Issue | 7 | Pages | 1912-1923.e9 |
| PubMed ID | 30428357 | Mgi Jnum | J:271122 |
| Mgi Id | MGI:6278816 | Doi | 10.1016/j.celrep.2018.10.044 |
| Citation | Jansz N, et al. (2018) Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway. Cell Rep 25(7):1912-1923.e9 |
| abstractText | We and others have recently reported that the SMC protein Smchd1 is a regulator of chromosome conformation. Smchd1 is critical for the structure of the inactive X chromosome and at autosomal targets such as the Hox genes. However, it is unknown how Smchd1 is recruited to these sites. Here, we report that Smchd1 localizes to the inactive X via the Xist-HnrnpK-PRC1 (polycomb repressive complex 1) pathway. Contrary to previous reports, Smchd1 does not bind Xist or other RNA molecules with any specificity. Rather, the localization of Smchd1 to the inactive X is H2AK119ub dependent. Following perturbation of this interaction, Smchd1 is destabilized, which has consequences for gene silencing genome-wide. Our work adds Smchd1 to the PRC1 silencing pathway for X chromosome inactivation. |
