| First Author | Lorente M | Year | 2006 |
| Journal | Mech Dev | Volume | 123 |
| Issue | 4 | Pages | 312-20 |
| PubMed ID | 16624538 | Mgi Jnum | J:109284 |
| Mgi Id | MGI:3628673 | Doi | 10.1016/j.mod.2006.02.003 |
| Citation | Lorente M, et al. (2006) Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech Dev 123(4):312-20 |
| abstractText | Polycomb group (PcG) proteins participate in the maintenance of transcriptionally repressed state of genes relevant to cell differentiation. Here, we show anterior homeotic transformations of the axial skeleton of YY1(+/-) mice. We find that the penetrance of some of these alterations was reduced in mice that are deficient in the class II PcG gene Ring1/Ring1A, indicating a genetic interaction between those two genes. Further support for this interaction is an abnormal anterior eye formation in Ring1-deficient mice, which is enhanced in compound YY1(+/-)Ring1(-/-) mice. In addition, YY1 forms complexes with Ring1 and other class II PcG proteins such as Rnf2 and Bmi1 in GST pull down experiments in transfected cells. These findings provide evidence for a PcG function for YY1 in vertebrates. |
