| First Author | Holmes ML | Year | 2006 |
| Journal | Genes Dev | Volume | 20 |
| Issue | 8 | Pages | 933-8 |
| PubMed ID | 16618805 | Mgi Jnum | J:108330 |
| Mgi Id | MGI:3623701 | Doi | 10.1101/gad.1396206 |
| Citation | Holmes ML, et al. (2006) Repression of Flt3 by Pax5 is crucial for B-cell lineage commitment. Genes Dev 20(8):933-8 |
| abstractText | Early B-lymphopoiesis requires the growth-factor receptors, IL-7R and Flt3, and the activity of a number of transcription factors. One factor, Pax5, is required for commitment to the B-cell lineage, although the molecular mechanism by which this occurs is unknown. We demonstrate here that an important function of Pax5 is to repress Flt3 transcription in B-cell progenitors, as Pax5-deficient pro-B cells express abundant Flt3 that is rapidly silenced upon the reintroduction of Pax5, whereas enforced expression of Flt3 in wild-type progenitors significantly impairs B-cell development. These findings demonstrate that the repression of Flt3 by Pax5 is essential for normal B-lymphopoiesis. |
