| First Author | Marusić-Galesić S | Year | 1995 |
| Journal | Immunology | Volume | 85 |
| Issue | 3 | Pages | 442-6 |
| PubMed ID | 7558133 | Mgi Jnum | J:110784 |
| Mgi Id | MGI:3641041 | Citation | Marusic-Galesic S, et al. (1995) Increased number of CD4-CD8+ MHC class II-specific T cells in MHC class II-deficient mice. Immunology 85(3):442-6 |
| abstractText | Targeted disruption of the A beta-encoding gene of H2b mice abolishes major histocompatibility complex (MHC) class II expression and results in a failure to develop CD4+8- T cells. Besides this major effect, the lack of class II expression affects the level of T-cell receptor (TCR) and CD4 expression on differentiating thymocytes. Moreover, there is no class II-mediated negative selection of thymocytes. All this could result in TCR repertoire changes of the CD4-8+ T-cell subpopulation, which apparently develops normally in these mice. To test this hypothesis, the class II reactivity of CD4-8+ T cells from class II-deficient (class II0) mice was analysed. It was found that CD4-8+ T cells from class II0 but not from class II-expressing mice developed a significant level of cytotoxicity against class II-expressing target cells. These results demonstrate an influence of MHC class II molecules on the TCR repertoire of CD4-8+ T cells. |
