| First Author | Wyss L | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 9 | Pages | 1093-101 |
| PubMed ID | 27478940 | Mgi Jnum | J:259155 |
| Mgi Id | MGI:6142433 | Doi | 10.1038/ni.3522 |
| Citation | Wyss L, et al. (2016) Affinity for self antigen selects Treg cells with distinct functional properties. Nat Immunol 17(9):1093-101 |
| abstractText | The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and controlled lympho-proliferation in peripheral lymph nodes. GITR(lo)PD-1(lo)CD25(lo) (Triple(lo)) Treg cells were less self-reactive and limited the development of colitis by promoting the conversion of CD4(+) Tconv cells into induced Treg cells (iTreg cells). Although Foxp3-deficient (Scurfy) mice lacked Treg cells, they contained Triple(hi)-like and Triple(lo)-like CD4(+) T cells zsuper> T cells infiltrated the skin, whereas Scurfy Triple(lo)CD4(+) T cells induced colitis and wasting disease. These findings indicate that the affinity of the T cell antigen receptor for self antigen drives the differentiation of Treg cells into distinct subsets with non-overlapping regulatory activities. |
