| First Author | Gore Y | Year | 2008 |
| Journal | J Biol Chem | Volume | 283 |
| Issue | 5 | Pages | 2784-92 |
| PubMed ID | 18056708 | Mgi Jnum | J:131317 |
| Mgi Id | MGI:3773489 | Doi | 10.1074/jbc.M703265200 |
| Citation | Gore Y, et al. (2008) Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. J Biol Chem 283(5):2784-92 |
| abstractText | Macrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that regulates subsequent adaptive responses. It was previously shown that in macrophages, MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway. In the current study, we investigated the role of MIF in B cell survival. We show that in B lymphocytes, MIF initiates a signaling cascade that involves Syk and Akt, leading to NF-kappaB activation, proliferation, and survival in a CD74- and CD44-dependent manner. Thus, MIF regulates the adaptive immune response by maintaining the mature B cell population. |
