| First Author | Shachar I | Year | 1996 |
| Journal | Science | Volume | 274 |
| Issue | 5284 | Pages | 106-8 |
| PubMed ID | 8810244 | Mgi Jnum | J:113050 |
| Mgi Id | MGI:3664383 | Doi | 10.1126/science.274.5284.106 |
| Citation | Shachar I, et al. (1996) Requirement for invariant chain in B cell maturation and function. Science 274(5284):106-8 |
| abstractText | Previously the role of invariant chain (Ii) had been described only as a chaperone that facilitates folding and transport of major histocompatability complex class II molecules; here it is shown that Ii is required for B cell development. B cells from mice lacking Ii were found to have a low response to T-independent type II antigen and could not proliferate after the mice were injected with antigen. Study of cell surface markers revealed a developmental arrest that prevented immature virgin B cells from becoming mature B cells in the periphery. This block was independent of major histocompatability complex class II expression and was an intrinsic feature of B cells that correlated with the amount of Ii. Thus, Ii participates by an unknown mechanism in B cell maturation. |
