| First Author | Schori H | Year | 2007 |
| Journal | J Immunol | Volume | 178 |
| Issue | 1 | Pages | 163-71 |
| PubMed ID | 17182551 | Mgi Jnum | J:141943 |
| Mgi Id | MGI:3820049 | Doi | 10.4049/jimmunol.178.1.163 |
| Citation | Schori H, et al. (2007) Genetic manipulation of CD74 in mouse strains of different backgrounds can result in opposite responses to central nervous system injury. J Immunol 178(1):163-71 |
| abstractText | The ability to recover from CNS injuries is strain dependent. Transgenic mice that weakly express the p41 CD74 isoform (an integral membrane protein functioning as a MHC class II chaperone) on an I-A(b) genetic background have normal CD4(+) T cell populations and normal surface expression of MHC class II, but their B cell development is arrested while the cells are still immature. After a CNS injury, these mice recover better than their matched wild-type controls. We generated p41-transgenic mice on an I-A(d) background (p41-I-A(d) mice), and found that their recovery from CNS injuries was worse than that of controls. A correlative inverse effect was seen with respect to the kinetics of T cell and B cell recruitment to the injured CNS and the expression of insulin-like growth factor at the lesion site. These results, besides verifying previous findings that B cells function in the damaged CNS, demonstrate that the outcome of a particular genetic manipulation may be strain dependent. |
