| First Author | Del Río JA | Year | 2004 |
| Journal | Curr Biol | Volume | 14 |
| Issue | 10 | Pages | 840-50 |
| PubMed ID | 15186740 | Mgi Jnum | J:90620 |
| Mgi Id | MGI:3044300 | Doi | 10.1016/j.cub.2004.04.046 |
| Citation | Del Rio JA, et al. (2004) MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance. Curr Biol 14(10):840-50 |
| abstractText | BACKGROUND: The signaling cascades governing neuronal migration and axonal guidance link extracellular signals to cytoskeletal components. MAP1B is a neuron-specific microtubule-associated protein implicated in the crosstalk between microtubules and actin filaments. RESULTS: Here we show that Netrin 1 regulates, both in vivo and in vitro, mode I MAP1B phosphorylation, which controls MAP1B activity, in a signaling pathway that depends essentially on the kinases GSK3 and CDK5. We also show that map1B-deficient neurons from the lower rhombic lip and other brain regions have reduced chemoattractive responses to Netrin 1 in vitro. Furthermore, map1B mutant mice have severe abnormalities, similar to those described in netrin 1-deficient mice, in axonal tracts and in the pontine nuclei. CONCLUSIONS: These data indicate that MAP1B phosphorylation is controlled by Netrin 1 and that the lack of MAP1B impairs Netrin 1-mediated chemoattraction in vitro and in vivo. Thus, MAP1B may be a downstream effector in the Netrin 1-signaling pathway. |
