| First Author | Shatzmiller RA | Year | 2008 |
| Journal | Neuroscience | Volume | 157 |
| Issue | 3 | Pages | 621-36 |
| PubMed ID | 18940235 | Mgi Jnum | J:144653 |
| Mgi Id | MGI:3831472 | Doi | 10.1016/j.neuroscience.2008.09.031 |
| Citation | Shatzmiller RA, et al. (2008) Graded expression of netrin-1 by specific neuronal subtypes in the adult mammalian striatum. Neuroscience 157(3):621-36 |
| abstractText | Netrins are a family of secreted proteins that function as axon guidance cues during neural development. High levels of netrin-1 expressed by the embryonic ganglionic eminence, the precursor of the adult striatum, direct axons that pioneer the internal capsule. Here we describe netrin-1 expression by neurons distributed throughout the striatum of the adult mouse. Differences were detected in the number and type of neurons expressing netrin-1 in different regions of the striatum. Most neurons in the ventral striatum, including projection neurons and cholinergic interneurons, express netrin-1. In contrast, netrin-1 expression is largely limited to cholinergic interneurons in the dorsal striatum, and the proportion of cholinergic interneurons that express netrin-1 decreases along rostral-caudal and ventral-dorsal axes. Regional differences in expression in the adult striatum suggest that netrin-1 not only influences the development of striatal circuitry but may also participate in the maintenance and plasticity of connections in the adult brain. |
