| First Author | Widmer FC | Year | 2022 |
| Journal | Elife | Volume | 11 |
| PubMed ID | 35170429 | Mgi Jnum | J:324805 |
| Mgi Id | MGI:6890115 | Doi | 10.7554/eLife.71476 |
| Citation | Widmer FC, et al. (2022) NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning. Elife 11:e71476 |
| abstractText | The experience of coupling between motor output and visual feedback is necessary for the development of visuomotor skills and shapes visuomotor integration in visual cortex. Whether these experience-dependent changes of responses in V1 depend on modifications of the local circuit or are the consequence of circuit changes outside of V1 remains unclear. Here, we probed the role of N-methyl-d-aspartate (NMDA) receptor-dependent signaling, which is known to be involved in neuronal plasticity, in mouse primary visual cortex (V1) during visuomotor development. We used a local knockout of NMDA receptors and a photoactivatable inhibition of CaMKII in V1 during the first visual experience to probe for changes in neuronal activity in V1 as well as the influence on performance in a visuomotor task. We found that a knockout of NMDA receptors before, but not after, first visuomotor experience reduced responses to unpredictable stimuli, diminished the suppression of predictable feedback in V1, and impaired visuomotor skill learning later in life. Our results demonstrate that NMDA receptor-dependent signaling in V1 is critical during the first visuomotor experience for shaping visuomotor integration and enabling visuomotor skill learning. |
