| First Author | Gray SR | Year | 2021 |
| Journal | Sci Adv | Volume | 7 |
| Issue | 51 | Pages | eabk1378 |
| PubMed ID | 34919424 | Mgi Jnum | J:350033 |
| Mgi Id | MGI:6842840 | Doi | 10.1126/sciadv.abk1378 |
| Citation | Gray SR, et al. (2021) Noradrenergic terminal short-term potentiation enables modality-selective integration of sensory input and vigilance state. Sci Adv 7(51):eabk1378 |
| abstractText | Recent years have seen compelling demonstrations of the importance of behavioral state on sensory processing and attention. Arousal plays a dominant role in controlling brain-wide neural activity patterns, particularly through modulation by norepinephrine. Noradrenergic brainstem nuclei, including locus coeruleus, can be activated by stimuli of multiple sensory modalities and broadcast modulatory signals via axonal projections throughout the brain. This organization might suggest proportional brain-wide norepinephrine release during states of heightened vigilance. Here, however, we have found that low-intensity, nonarousing visual stimuli enhanced vigilance-dependent noradrenergic signaling locally in visual cortex, revealed using dual-site fiber photometry to monitor noradrenergic Ca(2+) responses of astroglia simultaneously in cerebellum and visual cortex and two-photon microscopy to monitor noradrenergic axonal terminal Ca(2+) dynamics. Nitric oxide, following N-methyl-d-aspartate receptor activation in neuronal nitric oxide synthase-positive interneurons, mediated transient acceleration of norepinephrine-dependent astroglia Ca(2+) activation. These findings reveal a candidate cortical microcircuit for sensory modality-selective modulation of attention. |
