| First Author | Tsien JZ | Year | 1996 |
| Journal | Cell | Volume | 87 |
| Issue | 7 | Pages | 1327-38 |
| PubMed ID | 8980238 | Mgi Jnum | J:37457 |
| Mgi Id | MGI:84850 | Doi | 10.1016/s0092-8674(00)81827-9 |
| Citation | Tsien JZ, et al. (1996) The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 87(7):1327-38 |
| abstractText | We have produced a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout. The mutant mice grow into adulthood without obvious abnormalities. Adult mice lack NMDA receptor-mediated synaptic currents and long-term potentiation in the CA1 synapses and exhibit impaired spatial memory but unimpaired nonspatial learning. Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories. |
