| First Author | Lindeman GJ | Year | 1998 |
| Journal | Genes Dev | Volume | 12 |
| Issue | 8 | Pages | 1092-8 |
| PubMed ID | 9553039 | Mgi Jnum | J:47283 |
| Mgi Id | MGI:1203258 | Doi | 10.1101/gad.12.8.1092 |
| Citation | Lindeman GJ, et al. (1998) A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev 12(8):1092-8 |
| abstractText | Homozygous E2F-5 knockout embryos and mice have been generated. Although embryonic development appeared normal, newborn mice developed nonobstructive hydrocephalus, suggesting excessive cerebrospinal fluid (CSF) production. Although the CSF-producing choroid plexus displayed normal cellular organization, it contained abundant electron-lucent epithelial cells, consistent with excessive CSF secretory activity. Moreover, E2F-5 CNS expression in normal animals was largely confined to the choroid plexus. Cell cycle kinetics were not perturbed in homozygous knockout embryo fibroblasts. Thus, E2F-5 is not essential for cell proliferation. Rather, it affects the secretory behavior of a differentiated neural tissue. |
