| First Author | Held W | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 4 | Pages | 433-42 |
| PubMed ID | 10549625 | Mgi Jnum | J:110534 |
| Mgi Id | MGI:3640456 | Doi | 10.1016/s1074-7613(00)80118-1 |
| Citation | Held W, et al. (1999) Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1. Immunity 11(4):433-42 |
| abstractText | Families of clonally expressed major histocompatibility complex (MHC) class I-specific receptors provide specificity to and regulate the function of natural killer (NK) cells. One of these receptors, mouse Ly49A, is expressed by 20% of NK cells and inhibits the killing of H-2D(d) but not D(b)-expressing target cells. Here, we show that the trans-acting factor TCF-1 binds to two sites in the Ly49A promoter and regulates its activity. Moreover, we find that TCF-1 determines the size of the Ly49A NK cell subset in vivo in a dosage-dependent manner. We propose that clonal Ly49A acquisition during NK cell development is regulated by TCF-1. |
