| First Author | Harly C | Year | 2020 |
| Journal | Front Immunol | Volume | 11 |
| Pages | 470 | PubMed ID | 32265924 |
| Mgi Jnum | J:337301 | Mgi Id | MGI:6729490 |
| Doi | 10.3389/fimmu.2020.00470 | Citation | Harly C, et al. (2020) A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments. Front Immunol 11:470 |
| abstractText | The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendritic cells that we find express Tcf7. We identified a 1 kb regulatory element crucial for the initiation of Tcf7 expression in T cells and innate lymphoid cells, but dispensable for Tcf7 expression in Tcf7-expressing dendritic cells. Within this region, we identified a Notch binding site important for the initiation of Tcf7 expression in T cells but not in innate lymphoid cells. Our work establishes that the same regulatory element is used by distinct transcriptional controllers to initiate Tcf7 expression in T cells and ILCs. |
