| First Author | Yang Q | Year | 2013 |
| Journal | Immunity | Volume | 38 |
| Issue | 4 | Pages | 694-704 |
| PubMed ID | 23601684 | Mgi Jnum | J:196648 |
| Mgi Id | MGI:5488987 | Doi | 10.1016/j.immuni.2012.12.003 |
| Citation | Yang Q, et al. (2013) T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity 38(4):694-704 |
| abstractText | Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7(-/-) mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells. |
