| First Author | Siddiqui I | Year | 2019 |
| Journal | Immunity | Volume | 50 |
| Issue | 1 | Pages | 195-211.e10 |
| PubMed ID | 30635237 | Mgi Jnum | J:282507 |
| Mgi Id | MGI:6381093 | Doi | 10.1016/j.immuni.2018.12.021 |
| Citation | Siddiqui I, et al. (2019) Intratumoral Tcf1(+)PD-1(+)CD8(+) T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy. Immunity 50(1):195-211.e10 |
| abstractText | Checkpoint blockade mediates a proliferative response of tumor-infiltrating CD8(+) T lymphocytes (TILs). The origin of this response has remained elusive because chronic activation promotes terminal differentiation or exhaustion of tumor-specific T cells. Here we identified a subset of tumor-reactive TILs bearing hallmarks of exhausted cells and central memory cells, including expression of the checkpoint protein PD-1 and the transcription factor Tcf1. Tcf1(+)PD-1(+) TILs mediated the proliferative response to immunotherapy, generating both Tcf1(+)PD-1(+) and differentiated Tcf1(-)PD-1(+) cells. Ablation of Tcf1(+)PD-1(+) TILs restricted responses to immunotherapy. Tcf1 was not required for the generation of Tcf1(+)PD-1(+) TILs but was essential for the stem-like functions of these cells. Human TCF1(+)PD-1(+) cells were detected among tumor-reactive CD8(+) T cells in the blood of melanoma patients and among TILs of primary melanomas. Thus, immune checkpoint blockade relies not on reversal of T cell exhaustion programs, but on the proliferation of a stem-like TIL subset. |
