| First Author | Fischer-Riepe L | Year | 2020 |
| Journal | J Allergy Clin Immunol | Volume | 146 |
| Issue | 5 | Pages | 1137-1151 |
| PubMed ID | 32199911 | Mgi Jnum | J:316783 |
| Mgi Id | MGI:6819532 | Doi | 10.1016/j.jaci.2020.02.034 |
| Citation | Fischer-Riepe L, et al. (2020) CD163 expression defines specific, IRF8-dependent, immune-modulatory macrophages in the bone marrow. J Allergy Clin Immunol 146(5):1137-1151 |
| abstractText | BACKGROUND: Scavenger receptor CD163 is exclusively expressed on monocytes/macrophages and is widely used as a marker for alternatively activated macrophages. However, the role of CD163 is not yet clear. OBJECTIVES: We sought to examine the function of CD163 in steady-state as well as in sterile and infectious inflammation. METHODS: Expression of CD163 was analyzed under normal and inflammatory conditions in mice. Functional relevance of CD163 was investigated in models of inflammation in wild-type and CD163(-/-) mice. RESULTS: We describe a subpopulation of bone marrow-resident macrophages (BMRMs) characterized by a high expression of CD163 and functionally distinct from classical bone marrow-derived macrophages. Development of CD163(+) BMRMs is strictly dependent on IFN regulatory factor-8. CD163(+) BMRMs show a specific transcriptome and cytokine secretion pattern demonstrating a specific immunomodulatory profile of these cells. Accordingly, CD163(-/-) mice show a stronger inflammation in allergic contact dermatitis, indicating a regulatory role of CD163. However, CD163(-/-) mice are highly susceptible to S aureus infections, demonstrating the relevance of CD163 for antimicrobial defense as well. CONCLUSIONS: Our data indicate that anti-inflammatory and immunosuppressive mechanisms are not necessarily associated with a decreased antimicrobial activity. In contrast, our data define a novel macrophage population that controls overwhelming inflammation on one hand but is also necessary for an effective control of infections on the other hand. |
