| First Author | Zijlstra M | Year | 1990 |
| Journal | Nature | Volume | 344 |
| Issue | 6268 | Pages | 742-6 |
| PubMed ID | 2139497 | Mgi Jnum | J:80910 |
| Mgi Id | MGI:2447505 | Doi | 10.1038/344742a0 |
| Citation | Zijlstra M, et al. (1990) Beta 2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. Nature 344(6268):742-6 |
| abstractText | Mice homozygous for a beta 2-microglobulin gene disruption do not express any detectable beta 2-m protein. They express little if any functional major histocompatibility complex (MHC) class I antigen on the cell surface yet are fertile and apparently healthy. They show a normal distribution of gamma delta, CD4+8+ and CD4+8- T cells, but have no mature CD4-8+ T cells and are defective in CD4-8+ T cell-mediated cytotoxicity. Our results strongly support earlier evidence that MHC class I molecules are crucial for positive selection of T cell antigen receptor alpha beta+ CD4-8+ T cells in the thymus and call into question the non-immune functions that have been ascribed to MHC class I molecules. |
