| First Author | Robey E | Year | 1996 |
| Journal | Cell | Volume | 87 |
| Issue | 3 | Pages | 483-92 |
| PubMed ID | 8898201 | Mgi Jnum | J:93005 |
| Mgi Id | MGI:3055478 | Doi | 10.1016/s0092-8674(00)81368-9 |
| Citation | Robey E, et al. (1996) An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87(3):483-92 |
| abstractText | Notch is a transmembrane receptor that controls cell fate decisions in Drosophila and whose role in mammalian cell fate decisions is beginning to be explored. We are investigating the role of Notch in a well-studied mammalian cell fate decision: the choice between the CD8 and CD4 T cell lineages. Here we report that expression of an activated form of Notch1 in developing T cells of the mouse leads to both an increase in CD8 lineage T cells and a decrease in CD4 lineage T cells. Expression of activated Notch permits the development of mature CD8 lineage thymocytes even in the absence of class I major histocompatability complex (MHC) proteins, ligands that are normally required for the development of these cells. However, activated Notch is not sufficient to promote CD8 cell development when both class I and class II MHC are absent. These results implicate Notch as a participant in the CD4 versus CD8 lineage decision. |
