| First Author | Zietara N | Year | 2011 |
| Journal | Eur J Immunol | Volume | 41 |
| Issue | 11 | Pages | 3125-34 |
| PubMed ID | 21809338 | Mgi Jnum | J:179525 |
| Mgi Id | MGI:5302607 | Doi | 10.1002/eji.201041092 |
| Citation | Zietara N, et al. (2011) ICOS-dependent stimulation of NKT cells by marginal zone B cells. Eur J Immunol 41(11):3125-34 |
| abstractText | Marginal zone (MZ) B cells express high levels of CD1d molecules. In accordance, MZ B cells, like splenic conventional DCs (cDCs), efficiently trigger NKT-cell proliferation. Importantly, MZ B cells exclusively induced production of IL-4 and IL-13 by such cells whereas cDCs induced robust production of mainly IFN-gamma. NKT-cell proliferation, IL-4 and IL-13 production induced by MZ B cells were dependent on ICOS/ICOS ligand interaction while IFN-gamma and IL-17 induction by cDCs required glucocorticoid-induced TNF receptor/glucocorticoid-induced TNF receptor ligand interplay. Our data illustrate that both MZ B cells and cDCs act as efficient APCs for NKT cells and might differentially influence the quality of the subsequent immune response. |
