| First Author | Pereira P | Year | 1992 |
| Journal | EMBO J | Volume | 11 |
| Issue | 1 | Pages | 25-31 |
| PubMed ID | 1531458 | Mgi Jnum | J:111105 |
| Mgi Id | MGI:3653021 | Doi | 10.1002/j.1460-2075.1992.tb05023.x |
| Citation | Pereira P, et al. (1992) Blockade of transgenic gamma delta T cell development in beta 2-microglobulin deficient mice. EMBO J 11(1):25-31 |
| abstractText | The gamma delta T cell receptor (TCR) of the hybridoma KN6 recognizes the self molecule encoded by a class I gene which maps within the TL region of the major histocompatibility complex (MHC) of H-2b mice. Mice transgenic (Tg) for this TCR were crossed with mice genetically deficient in beta 2-microglobulin (beta 2m). No mature Tg gamma delta T cells were detected in the thymus or the spleen of the beta 2m- gamma delta Tg mice. We conclude that interaction between the Tg gamma delta TCR and a beta 2m-associated molecule (probably an MHC class I molecule) is required for the generation of mature Tg gamma delta T cells. |
