| First Author | Boucheron N | Year | 2014 |
| Journal | Nat Immunol | Volume | 15 |
| Issue | 5 | Pages | 439-448 |
| PubMed ID | 24681565 | Mgi Jnum | J:209977 |
| Mgi Id | MGI:5569196 | Doi | 10.1038/ni.2864 |
| Citation | Boucheron N, et al. (2014) CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol 15(5):439-48 |
| abstractText | Molecular mechanisms that maintain lineage integrity of helper T cells are largely unknown. Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucial regulators of this process. Loss of HDAC1 and HDAC2 during late T cell development led to the appearance of major histocompatibility complex (MHC) class II-selected CD4(+) helper T cells that expressed CD8-lineage genes such as Cd8a and Cd8b1. HDAC1 and HDAC2-deficient T helper type 0 (TH0) and TH1 cells further upregulated CD8-lineage genes and acquired a CD8(+) effector T cell program in a manner dependent on Runx-CBFbeta complexes, whereas TH2 cells repressed features of the CD8(+) lineage independently of HDAC1 and HDAC2. These results demonstrate that HDAC1 and HDAC2 maintain integrity of the CD4 lineage by repressing Runx-CBFbeta complexes that otherwise induce a CD8(+) effector T cell-like program in CD4(+) T cells. |
