| First Author | Rimer M | Year | 2005 |
| Journal | Neuroreport | Volume | 16 |
| Issue | 3 | Pages | 271-5 |
| PubMed ID | 15706234 | Mgi Jnum | J:103529 |
| Mgi Id | MGI:3610263 | Doi | 10.1097/00001756-200502280-00014 |
| Citation | Rimer M, et al. (2005) Neuregulin-1 immunoglobulin-like domain mutant mice: clozapine sensitivity and impaired latent inhibition. Neuroreport 16(3):271-5 |
| abstractText | Genetic and behavioral studies in humans and mouse mutants have implicated the gene encoding neuregulin-1 (Nrg-1) as a candidate susceptibility gene for schizophrenia. We examined the behavior of mice heterozygous for a mutation in neuregulin-1's immunoglobulin (Ig)-like domain (Ig-nrg-1 mice). We found that these animals displayed behaviors related to a schizophrenia-like phenotype, such as clozapine suppression of open-field and running wheel activity and impaired latent inhibition. Contrary to findings with other nrg-1 mutants, Ig-nrg-1 mice did not exhibit significantly elevated locomotion relative to littermate controls. These results suggest that Ig-Nrg-1's contribute to some - but not all - aspects of the schizophrenia-like phenotype of nrg-1 mutants, and further support nrg-1 as a candidate gene for schizophrenia. |
