| First Author | Hnasko TS | Year | 2004 |
| Journal | Brain Res | Volume | 1023 |
| Issue | 2 | Pages | 309-18 |
| PubMed ID | 15374756 | Mgi Jnum | J:92829 |
| Mgi Id | MGI:3054588 | Doi | 10.1016/j.brainres.2004.07.051 |
| Citation | Hnasko TS, et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res 1023(2):309-18 |
| abstractText | Dopamine-deficient (DD) mice become hypophagic and die of starvation by 3 to 4 weeks of age unless dopamine is restored by daily treatment with l-3-4-dihydroxyphenylalanine (l-dopa). We demonstrate here that DD mice mount qualitatively normal counter-regulatory blood glucose responses to insulin and 2-deoxy-d-glucose (2-DG). However, unlike control mice, DD mice fail to eat in response to acute glucoprivation induced by insulin or 2-DG. They also have a severely blunted response to central administration of peptide YY (PYY). Viral-mediated restoration of dopamine synthesis to the central caudate putamen (CPu) of DD mice rescues feeding and survival. However, this treatment fails to restore insulin- and 2-DG-induced feeding despite normalizing feeding in response to food deprivation and PYY. Since dopamine signaling in the CPu is not sufficient for glucoprivation-induced feeding, we propose that this feeding behavior may be mediated by dopamine in an anatomically distinct brain region. |
