| First Author | Miyakawa T | Year | 1994 |
| Journal | Brain Res Mol Brain Res | Volume | 27 |
| Issue | 1 | Pages | 179-82 |
| PubMed ID | 7877449 | Mgi Jnum | J:21225 |
| Mgi Id | MGI:69250 | Doi | 10.1016/0169-328x(94)90201-1 |
| Citation | Miyakawa T, et al. (1994) Increased fearfulness of Fyn tyrosine kinase deficient mice. Brain Res Mol Brain Res 27(1):179-82 |
| abstractText | Fyn-deficient mice were produced by inserting the beta-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli. |
