| First Author | Miyakawa T | Year | 1997 |
| Journal | Science | Volume | 278 |
| Issue | 5338 | Pages | 698-701 |
| PubMed ID | 9381182 | Mgi Jnum | J:43707 |
| Mgi Id | MGI:1098368 | Doi | 10.1126/science.278.5338.698 |
| Citation | Miyakawa T, et al. (1997) Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function [see comments]. Science 278(5338):698-701 |
| abstractText | Animals vary in their sensitivity to ethanol, a trait at least partly determined by genetic factors. In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated. These mice were hypersensitive to the hypnotic effect of ethanol. The administration of ethanol enhanced tyrosine phosphorylation of the N-methyl-D-aspartate receptor (NMDAR) in the hippocampus of control mice but not in Fyn-deficient mice. An acute tolerance to ethanol inhibition of NMDAR-mediated excitatory postsynaptic potentials in hippocampal slices developed in control mice but not in Fyn-deficient mice. These results indicate that Fyn affects behavioral, biochemical, and physiological responses to ethanol. |
